ABSTRACT

Liposarcomas of the mediastinum (LM) are unusual tumors characterized by compression of neighboring structures and frequent recurrences. According to a review of the literature, surgical resection is the most effective treatment. The 4 most important prognostic variables are, grade, size, localization of the primary tumor and the completeness resection. Preoperative biopsy and optimal approach are very important for an optimal and curative surgery. LM are relatively uncommon tumors and there are no established guidelines for the treatment. The evaluation by oncology team who have expertise in the field is recommended. We report one case of a giant mediastinal liposarcoma.

KEYWORDS

Liposarcoma, mediastinum, .

REFERENCES

1. Enzinger FM, Weiss SW, editores. Liposarcoma. Soft tissue tumors. 3rd ed. St. Louis: Mosby; 1995. p.431-66.

2. Skubitz K, DÁdamo D. Sarcoma. Mayo Clin Proc 2007; 82(11): 1409-1432.

3. Rivo JE, Cañizares MA, García-Fontán E, Albort J, González-Piñeiro A, Peñalver R. Liposarcomas mediastínicos de localización atípica. Aportación de 2 casos. Cir Esp 2005; 77(2): 99-101.

4. Buró M, Ihde JK, Hajdu SI, Smith JW, Bains MS, Downey R, et al. Primary sarcomas of the mediastinum: results of therapy. J Torca Cardiovasc Surg 1998; 115: 671-80.

5. Hirai S, Hamanaka Y, Mitsui N, Uegami S, Matsuura Y. Surgical resection of primary liposarcoma of the anterior mediastinum. Ann Thorac Cardiovasc Surg 2008; 14(1):8-41.

6. Kara M, Ozkan M, Dizbay SS, Avukcu ST. Successful removal of a giant recurrent mediastinal liposarcoma involving boy hemithoraces. Eur J Cardiothorac Surg 2001; 20: 647-49.

7. Morcillo A, Calvo V, Pastor J. Liposarcoma mediastínico recidivante. Arch Bronconeumol 1998; 34: 273.

8. Freixinet J, Santana N, Rodríguez P. Liposarcoma mediastínico recidivante. Arch Bronconeumol 1999; 35: 144-5.

9. Tavecchino M, Simone M, Erba E, Chiolo I, Liberi G, Foiani M, D´Incalci M, Damia G. Role of homologous recombination in trabectedininduced DNA damage. Epub 2008; Feb 19. Eur J Cancer 2008 Mar; 44(4): 609-18.

10. Skubitz KM, Cheng EY, Clohisy DR, Thompson RC, Skubitz AP. Differential gene expression in liposarcoma, lipoma, and adipose tissue. Cancer Invest 2005; 23: 105-118.

11. Maki RG. Future directions for immunotherapeutic intervention against sarcomas. Curr Opin Oncol 2006; 18: 363-368.