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Immunological mechanisms of the inflammatory response in COPD

Juan M Reséndiz-Hernández, Ángel Camarena, Gloria Pérez-Rubio, Ramcés Falfán-Valencia





2010, Number 4

2010; 69 (4)






ABSTRACT

Chronic obstructive pulmonary disease is a complex chronic disease involving several types of cells and inflammatory mediators. The relationship between these cell types, cytokines, and the sequence of events culminating with progressive limitation of airflow and lung parenchyma destruction is not clear. It is recognized as a systemic disease with extrapulmonary implications in different organs. Several health problems are started by smoking snuff, beginning with the direct damage of lung tissue by harmful gases contained in cigarette smoke and subsequently by direct activation of macrophages, neutrophils and tissue resident cells by smoke particles and/or induction of repair processes. There are two hypotheses that attempt to explain this abnormal response: 1) an imbalance in the oxidant/anti-oxidants and 2) an imbalance in the protease/anti-proteases. About to cellular mechanisms involved in the local inflammatory process, has described the role of CD8 + T cells activated by alarm signals produced by antigen-presenting cells, which in turn have been activated by exposure to pathogens, toxins, mechanical damage and cigarette smoke.

KEYWORDS

COPD, lung inflammation, cytokines, inflammatory mediators, acute phase proteins.

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2010, Number 4

2010; 69 (4)