ABSTRACT

Bronchial asthma presents a series of mechanisms involved in its physiopathology which make it necessary to try to understand each one of them to identify what is predominating in a specific patient and in this direction guide the treatment. At present, it is a chimera to try to generalize the treatment of bronchial asthma in a specific treatment, which sometimes is very rigid and devoid of logical application. This situation has oriented the researches towards the genetics field with good results, although still far from identifying the genes of immune response involved in bronchial asthma. Identifying the frequency of specific antigens of histocompatibility present in patients with bronchial asthma without racial differences is a tool which can help us in this regard. That is why we studied 30 Mexican asthma patients using the microcytotoxicity technique to identify class I and class II alleles and evaluate the frequency of some of them in these patients. We found a statistically significant frequency of the DR4 allele in 54% of the studied patients, which coincides with some studies but is in contradiction with others.

KEYWORDS

Asthma, histocompatibility, genetics, allele, DR4.

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