ABSTRACT

The viruses: 1) sincitial respiratory, 2) measles, 3) parainfluenza and 4) of the mumps are the viruses of the family Paramixoviridae with major incidence in the man. These viruses are efficient instigators of the production of interferon of type the I and II (IFN-α/β and γ) and in the last years it has remained clear that these share proteins that act in the regulation of the immune system. The majority of the paramixovirus codify for proteins that activate inhibiting mechanisms of the production of the IFNs diminishing the efficiency of the immune response. In this article there are mentioned events that lead to the half-full production of the IFNs-mediate for the receptor of recognition of patterns (PRR’s) that in turn are activated by molecular patterns associated to pathogenic or PAMPs of each of these viruses. Has been described how they interdrive the different viral proteins (P/V/C, G and NS1 and 2). With it’s target cell and it describes how these four paramixovirus limit the production of PAMPs and inhibit cellular responses to interfere with the activities of PRR’s, MDA5 and RIG-I, inhibiting this way to diverse components of the route of signaling in the induction of the IFNs.

KEYWORDS

Interferon, Paramyxoviridae, PAMPs, PRR’s, TLR’s, MDA5, RIG-I.

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