Lung function analysis during the initial evaluation of patients with asthma. Obesity effect
José Luis Che-Morales , Arturo Cortés-Télles
2013, Number 4
2013; 72 (4)
ABSTRACT
Background: The association between asthma and obesity has taken great interest in clinical investigation. In México, Yucatan ranks first in prevalence of asthma and fourth in overweight or obesity. Methods: transversal and retrospective study aimed to describe the pulmonary function during the initial evaluation of patients with asthma. In addition, we explored the effect of obesity on pulmonary function by grouping the patients based on their body mass index. Results: 258 clinical files were analyzed. The mean age was 51 years. The mean FEV1 was 77%p and it was not different among all the groups (p = 0.26). One of every five spirometries are under normal values during the initial evaluation. Among all spirometries with an obstructive pattern, 47% were classified with mild obstruction. We documented an inverse relationship among the lung volumes measured on FVC and FEV1 with body mass index, nevertheless, it was not relevant taking in count the percent of predicted values. Conclusions: during the initial evaluation of patients with a diagnosis of asthma, the FEV1 was 77%p. In addition, 20% have normal lung function. Obesity does not contribute on deterioration of airway obstruction in the asthmatic patients.
Finucane MM, Stevens GA, Cowan MJ, et al.; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011;377:557-567.
Secretaría de Salud. Encuesta Nacional de Salud y Nutrición 2012, Síntesis Ejecutiva. Instituto Nacional de Salud Pública 2012. Accesible en: http://ensanut.insp.mx/doctos/ENSANUT2012_Sint_Ejec-24oct.pdf
Del-Rio-Navarro BE, Fanghänel G, Berber A, Sánchez-Reyes L, Estrada-Reyes E, Sienra-Monge J. The relationship between asthma symptoms and anthropometric markers of overweight in a Hispanic population. J Investig Allergol Clin Immunol 2003;13:118-123.
Monereo MS, Pavon PI, Molina BB, Vega PB, Alameda HC, López de la Torre CM. Calidad de vida relacionada con la salud y obesidad. Endocrinol Nutr 2000;47:81-88.
Vázquez-García JC. Obesidad y asma. Rev Invest Clin 2002;54:453-461.
Información Epidemiológica de Morbilidad. Anuario 2011. SUIVE/DGE/SALUD/Información Epidemiológica de Morbilidad, Anuario 2011. Versión ejecutiva. Último acceso: 25-04-2013
Roa-Castro FM, Toral-Freyre S, Roa-Castro VH, et al. Estimaciones sobre la tendencia del asma en México para el período 2008-2012. An Med (Mex) 2009;54:16-22.
Salome C, King G, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol 2010; 108: 206-211.
Thomson CC, Clark S, Camargo CA Jr; MARC Investigators. Body mass index and asthma severity among adults presenting to the emergency department. Chest 2003;124:795-802.
Fernández-Vega M, Vargas VM, Regalado-Pineda J, Chapela-Mendoza R, Salas-Hernández J. Características de pacientes asmáticos mexicanos atendidos en consulta externa. Rev Invest Clin 2005;57:513-521.
Soriano JB, Rabe KF, Vermeire PA. Predictors of poor asthma control in European adults. J Asthma 2003;40:803-813.
Williams JR. The Declaration of Helsinki and public health. Bull World Health Organ 2008;86:650-652.
Global Strategy for Asthma Management and Prevention. Updated 2012. Available from: www.ginasthma.org Access date: 01-05-2013
Miller MR, Hankinson J, Brusasco V, et al.; ATS/ERS Task Force. Standarization of spirometry. Eur Respir J 2005;26:319-338.
Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999;159:179-187.
Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J 2005;26:948-968.
World Health Organization: Obesity: Preventing and Managing the Global Epidemic Geneva: WHO; 1997. Available from: http://www.who.int/en/. Access date: 25-05-2013
Guidelines for the Diagnosis and Management of Asthma. EPR-3. 2007. The National Heart, Lung and Blood Institute. Available from: http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm Access date: 12-05-2013
Veiga J, Lopes AJ, Jansen JM, de Melo PM. Effects of airway obstruction on albuterol-mediated variations in the resistive and elastic properties of the respiratory system of patients with asthma. J Bras Pneumol 2009;35:645-652.
Limb SL, Brown KC, Wood RA, et al. Irreversible lung function deficits in young adults with a history of childhood asthma. J Allergy Clin Immunol 2005;116:1213-1219.
King CS, Moores LK. Clinical asthma syndromes and important asthma mimics. Respir Care 2008;53:568-580.
Sexton P, Black P, Wu L, et al. Fixed airflow obstruction among non-smokers with asthma: a case comparison study. J Asthma 2013;50:606-612. doi: 10.3109/02770903.2013.793706
Bumbacea D, Campbell D, Nguyen L, et al. Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J 2004;24:122-128.
Quirce S, Plaza V, Picado C, Vennera M, Casafont J. Prevalence of uncontrolled severe persistent asthma in pneumology and allergy hospital units in Spain. J Investig Allergy Clin Immunol 2011;21:466-471.
Hirota N, Martin JG. Mechanisms of airway remodeling. Chest 2013;144:1026-1032.
Ruppel GL. What is the clinical value of lung volumes? Respir Care 2012;57:26-35.
Iyer VN, Schroeder DR, Parker KO, Hyatt RE, Scanlon PD. The nonspecific pulmonary function test: longitudinal follow-up and outcomes. Chest 2011;139:878-886.
Velázquez-Chávez E, Che-Morales JL, Cortes-Télles A. Espirometría como herramienta en la detección de alteraciones en la función respiratoria. Reporte del Día Mundial de la Espirometría. Evid Med Invest Salud 2012;5: 124-130.
Cámara Nacional de la Industria del Vestido. ¿Cuánto mide México?, el tamaño sí importa. Boletín de prensa. Disponible en: http://www.canaive.org.mx/prensa. Fecha de acceso: 22-05-2013
Hankinson JL, Kawut SM, Shahar E, Smith LJ, Stukovsky KH, Barr RG. Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the multi-ethnic study of atherosclerosis (MESA) lung study. Chest 2010;137:138-145.
Pérez-Padilla J, Regalado-Pineda J, Vázquez-García JC. Reproducibilidad de espirometrías en trabajadores mexicanos y valores de referencia internacionales. Salud Pública Mex 2001;43:113-121.
Torre-Bouscoulet L, Pérez-Padilla R. Ajuste de varias ecuaciones de referencia espirométrica en una muestra poblacional en México. Salud Pública Mex 2006;48:466-473.
Pérez-Padilla R, Valdivia G, Muiño A, et al. Valores de referencia espirométrica en 5 grandes ciudades de Latinoamérica para sujetos de 40 o más años de edad. Arch Bronconeumol 2006;42:317-325.
Farah CS, Salome CM. Asthma and obesity: a known association but unknown mechanism. Respirology 2012;17:412-421.
Thomson CC, Clark S, Camargo CA Jr; MARC Investigators. Body mass index and asthma severity among adults presenting to the emergency department. Chest 2003;124:795-802.
Nicolacakis K, Skowronski ME, Coreno AJ, et al. Observations on the physiological interactions between obesity and asthma. J Appl Physiol 2008;105:1533-1541.