ABSTRACT

Background: Patients with chronic obstructive pulmonary disease (COPD) have a high prevalence of heart failure (HF). Patients with concurrent HF and COPD have worse prognosis. However, the impact of Right Heart Failure (RHF) on hospital mortality has not been explored. Objective: to evaluate the association between of right heart failure (RHF) and hospital mortality in COPD patients. Methods: An analytical cross-sectional study was performed in hospitalized COPD patients. The patients hospitalized between 2014 and 2015 were including in study. Results: Ninety-five patients diagnosed with COPD were analyzed: COPD alone (n = 25), COPD and HF with preserved ejection fraction (HFpEF) (n = 29), COPD and RHF (n = 41) and COPD and HF with reduced ejection fraction (HFrEF) (n = 0). The variables associated with risk of hospital mortality were RHF (OR: 10.91, 95% CI: 1.28 to 92.65, p = 0.029), stroke (OR: 14.4, 95% CI: 2.64 to 78.37, p 0.002), pulmonary thromboembolism (OR: 2.09, 95% CI: 1.47-2.98, ‹ 0.001) and chronic renal disease (OR: 4.08, 95% CI: 3.36 to 7.01, p ‹ 0.001). Finally, RHF with COPD subjects has 9.42 times more risk of hospital mortality (OR: 9.42, 95% CI: 1.00 to 88.31, p = 0.049) than COPD without RHF adjusted by confusing variables. Conclusion: RHF is a independient risk factor for hospital mortality in COPD patients.

KEYWORDS

Right heart failure, prognosis, chronic obstructive pulmonary disease, hospital mortality, right ventricular disfunction.

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