RESUMEN

El surgimiento de un nuevo componente del sistema renina-angiotensina, el receptor de renina/prorenina, provoca un giro inesperado en la interpretación de la fisiología de este sistema, cuyo papel clásico descrito es la regulación de la presión arterial. Este nuevo receptor aporta funciones a una proteína que hasta hace una década se pensaba sólo podía hidrolizar un sustrato (angiotensinógeno). Las evidencias de los últimos años señalan que el receptor renina/prorenina podría poseer un papel importante en la remodelación de la matriz extracelular en algunas patologías fibrosantes como el riñón y el corazón. En esta revisión se presentan los hallazgos más recientes del receptor renina/ prorenina y su participación en procesos fibrosantes que también podrían estar participando de manera importante en la patogénesis de la fibrosis pulmonar idiopática.

PALABRAS CLAVE

Fibrosis pulmonar idiopática, renina, prorenina, receptor renina/prorenina y angiotensina II.

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