ABSTRACT

The emergence of a new member of the renin-angiotensin system, the renin /prorenin receptor revealed an unexpected role of this system different to its classical in, the regulation of blood pressure. Recent evidences indicate that therenin/prorenin receptor could have an important role in extracellular matrix remodeling in several fibrosing disorders of kidney and heart. In this review we present the latest findings of the renin/prorenin receptor and its participation in fibrosing processes that may be relevant in the pathogenesis of idiopathic pulmonary fibrosis.

KEYWORDS

Idiopathic pulmonary fibrosis, renin, prorenin, renin/prorenin receptor y angiotensin II.

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