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New perspectives on carbonic anhydrase

Lorena Espinosa Monroy , Martha Patricia Sierra Vargas





2010, Number 4

2010; 69 (4)






ABSTRACT

Carbonic anhydrase is a zinc-dependent metalloenzyme that plays an important role in the hydration of CO2 to form HCO3- and H+. Among the five families described, AC-α family is found in humans, it is divided into four subgroups and fourteen isoforms. Its wide cellular distribution confers a versatile functionality. Studies reported recently, lead us to question about the role that this enzyme plays in the genesis, control and progress of lung diseases such as asthma, COPD and even atherosclerosis and cancer.

KEYWORDS

Carbonic anhydrase, carbon dioxide, bicarbonate, lung diseases.

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2010, Number 4

2010; 69 (4)