ABSTRACT

KEYWORDS

REFERENCES

1. Collins FS, Green ED, Guttmacher AE, Guyer MS; US National Human Genome Research Institute. A vision for the future of genomics research. Nature 2003;422(6934):835-847.

2. Watson JD, Crick FHC. Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 1953;171(4356):737-738.

3. Ohno S. So much «junk» DNA in our genome. In: Smith HH, editor. Evolution of genetic systems. New York: Gordon and Breach; 1972. p. 366-370.

4. Kuhn TS. The structure of scientific revolutions. University of Chicago Pres.; 1962.

5. Chen LL, Yang L. ALUternative Regulation for Gene Expression. Trends Cell Biol 2017;27(7):480-490. doi: 10.1016/j.tcb.2017.01.002.

6. Maston GA, Evans SK, Green MR. Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet 2006;7:29-59.

7. Gerstein MB, Kundaje A, Hariharan M, et al. Architecture of the human regulatory network derived from ENCODE data. Nature 2012;489(7414):91-100. doi: 10.1038/nature11245.

8. ENCODE Project Consortium. The ENCODE (ENCyclopedia of DNA Elements) Project. Science 2004;306(5696):636-640.

9. ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489(7414):57-74. doi: 10.1038/nature11247.

10. Flores M, Glusman G, Brogaard K, Price ND, Hood L. P4 medicine: how systems medicine will transform the healthcare sector and society. Per Med 2013;10(6):565-576.

11. Vanfleteren LE, Kocks JW, Stone IS, et al. Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? Thorax 2014;69(1):72-79. doi: 10.1136/thoraxjnl-2013-203602.