ABSTRACT

Solitary fibrous tumor is a rare neoplasm with particular characteristics. Initially described as a primary tumor of the pleura by Wagner in 1870, it has received various names including the hemangiopericytoma. The purpose of our study was to determine the number of solitary fibrous tumors operated in our institutions in the last 21 years. Material and methods: A retrospective cohort study is presented, which includes a review of the files of patients with lung masses diagnosed as solitary fibrous tumors by biopsy or surgical resection between 1996 and 2017. Results: Of the 1,192 patients operated on the thorax, 11 (0.92%) were diagnosed with a solitary fibrous tumor. The benign etiology was confirmed in 10 patients and 1 of malignant etiology. All showed a pleural origin, 10 of parietal pleura and 1 of visceral pleura. The average diameter of the masses was 16.8 cm. In 9 patients the resection was complete resulting in complete reexpansion of the lung whereas in two patients the tumor was unresectable. Both patients died during the follow-up. Conclusion: We present a series of patients with Solitary fibrous tumor of the pleura, mostly symptomatic, as a reflection of the large size and the conditions of practice in a developing country with multiple limitations; but which illustrates the presentation and behavior of these tumors and shows that despite its size, the possibility of a complete resection on a curative basis is possible.

KEYWORDS

Tumor, fibrous, solitary, pleura.

REFERENCES

1. Crnjac A, Veingerl B, Vidovic D, Kavalar R, Hojski A. Giant solitary fibrous tumour of the pleura. Case report and review of the literature. Radiol Oncol. 2015;49(4):395-401. Available from: https://doi.org/10.2478/raon-2014-0036

2. Demicco EG, Meyer C. Solitary fibrous tumor. UpToDate. [Access date 2015 December 18] Available from: https://www.uptodate.com/contents/solitary-fibrous-tumor

3. Yalcin CE, Tihan T. Solitary fibrous tumor/hemangiopericytoma dichotomy revisited: a restless family of neoplasms in the CNS. Adv Anat Pathol. 2016;23(2):104-111. Available from: https://doi.org/10.1097/pap.0000000000000103

4. Galateau-Salle F, Churg A, Roggli V, Travis WD; World Health Organization Committee for Tumors of the Pleura. The 2015 World Health Organization classification of tumors of the pleura: advances since the 2004 classification. J Thorac Oncol. 2016;11(2):142-154. Available from: https://doi.org/10.1016/j.jtho.2015.11.005

5. Penel N, Amela EY, Decanter G, Robin YM, Marec-Berard P. Solitary fibrous tumors and so-called hemangiopericytoma. Sarcoma. 2012:690251. Available from: https://doi.org/10.1155/2012/690251

6. Thway K, Ng W, Noujaim J, Jones RL, Fisher C. The current status of solitary fibrous tumor: diagnostic features, variants, and genetics. Int J Surg Pathol. 2016;24(4):281-292. Available from: https://doi.org/10.1177/1066896915627485

7. Thorgeirsson T, Isaksson HJ, Hardardottir H, Alfredsson H, Gudbjartsson T. Solitary fibrous tumors of the pleura: an estimation of population incidence. Chest. 2010;137(4):1005-1006. Available from: https://doi.org/10.1378/chest.09-2748

8. Chu X, Zhang L, Xue Z, Ren Z, Sun Ye, Wang M, et al. Solitary fibrous tumor of the pleura: an analysis of forty patients. J Thorac Dis. 2012;4(2):146-154. Available from: https://doi.org/10.3978/j.issn.2072-1439.2012.01.05

9. Abe M, Nomori H, Fukazawa M, Sugimura H, Narita M, Takeshi A. Giant solitary fibrous tumor of the pleura causing respiratory insufficiency: report of 3 cases. Ann Thorac Cardiovasc Surg. 2014;20:441-444. Available from: https://doi.org/10.5761/atcs.cr.13-00154

10. Rajagopal A, Toney B. Giant solitary fibrous tumor of the pleura presenting with syncope secondary to hypoglycemia. Chest. 2013;144(4):505A. Available from: https://doi.org/10.1378/chest.1679808

11. Weynand B, Noël H, Goncette L, Noirhomme P, Collard P. Solitary fibrous tumor of the pleura: a report of five cases diagnosed by transthoracic cutting needle biopsy. Chest. 1997;112(5):1424-1428. Available from: https://doi.org/10.1378/chest.112.5.1424

12. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. 1989;13(8):640-658. Available from: https://doi.org/10.1097/00000478-198908000-00003

13. Huang SC, Li CF, Kao YC, Chuang IC, Tai HC, Tsai JW, et al. The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors. Cancer Med. 2016;5(2):159-168. Available from: https://doi.org/10.1002/cam4.572

14. Shukla R, Patrini D, Borg E, Lawrence D, Hayward M, Panagiotopoulos N. The potential malignancy of a solitary fibrous tumour of the lung. Case Rep Pathol. 2015;2015:209490. Available from: https://doi.org/10.1155/2015/209490

15. Lahon B, Mercier O, Fadel E, Ghigna MR, Petkova B, Mussot S, et al. Solitary fibrous tumor of the pleura: outcomes of 157 complete resections in a single center. Ann Thorac Surg. 2012;94(2):394-400. Available from: https://doi.org/10.1016/j.athoracsur.2012.04.028

16. Takahama M, Kushibe K, Kawaguchi T, Kimura M, Taniguchi S. Video-assisted thoracoscopic surgery is a promising treatment for solitary fibrous tumor of the pleura. Chest. 2004;125(3):1144-1147. https://doi.org/10.1378/chest.125.3.1144

17. Boddaert G, Guiraudet P, Grand B, Venissac N, Pimpec-Barthes FL, Mouroux J, et al. Solitary fibrous tumors of the pleura: a poorly defined malignancy profile. Ann Thorac Surg. 2015;99(3):1025-1031. Available from: https://doi.org/10.1016/j.athoracsur.2014.10.035